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THERAPEUTIC AND PHARMACOLOGICAL MONITORING OF TACROLIMUS IN RENAL TRANSPLANT PATIENTS IN C.H.U TIZI OUZOU, ALGERIA.
(2019) KACI, Lylia; BADAOUI, L; KENDEL, A; NEKKAR, T; BOUDJELLIL, C; DAHMANI, D; MEKACHER., L.R
Immunosuppressants are now an essential treatment in the prevention of transplant rejection. Tacrolimus a calcineurin inhibitor, works by blocking the production of interleukin 2 by T cells and is currently the cornerstone of immunosuppressive treatment, but its side effects are many and varied (hypertension, diabetes , nephrotoxicity,...). The nephrotoxicity of tacrolimus is a particularly serious problem. Therapeutic and pharmacological monitoring of tacrolimus is a key element in the therapeutic management of renal transplant patients, allowing individual adaptation of prescribing to maintain drug exposure within a predefined concentration range (therapeutic targets) and thus improve efficacy while limiting toxicity. The determination of residual concentrations, is still widely used as a guide for individualizing tacrolimus doses